Publications

Nam D, Park J, Lee J, Son J, Kim JE*. mTOR potentiates senescent phenotypes and primary cilia formation after cisplatin-induced G2 arrest in retinal pigment epithelial cells. Cell Signal. 2024 Sep 7;124:111402. 

Ryu J, Lee SH, Kim S, Jeong JW, Kim KS, Nam S, Kim JE*. Urban dust particles disrupt mitotic progression by dysregulating Aurora kinase B-related functions. J Hazard Mater. 2023 Oct 5;459:132238. 

Ji SM, Choi JS, Lee JY, Kim S, Bae WY, Jang YW, Kim JE, Lee SH, Nam S, Jeong JW. Mild exposure to fine particulate matter promotes angiogenesis in non-small cell lung carcinoma. Environ Pollut. 2023 Jul 15;329:121715

Ryu J, Kim JE*. CCAR2 controls mitotic progression through spatiotemporal regulation of Aurora B. Cell Death Dis. 2022 Jun 7;13(6):534.

Lim J, Son J, Ryu J, Kim JE*. SIRT2 Affects Primary Cilia Formation by Regulating mTOR Signaling in Retinal Pigmented Epithelial Cells. Int J Mol Sci. 2020 Mar 24;21(6). pii: E2240.

Kim JE*. Bookmarking by histone methylation ensures chromosomal integrity during mitosis. (Review) Arch Pharm Res. 2019 Jun;42(6):466-480

Kim W, Ryu J, Kim JE*. CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells. Int J Mol Sci. 2019 Jan 1;20(1). pii: E131.

Ryu J, Pyo J, Lee CW, Kim JE*. An Aurora kinase inhibitor, AMG900, inhibits glioblastoma cell proliferation by disrupting mitotic progression. Cancer Med. 2018 Nov 21;7(11):5589-5603.

Choi JS, Bae WY, Ryu J, Park A, Nam S, Kim JE* (co-corresponding), Jeong JW*. Zingerone suppresses tumor development through decreasing cyclin D1 expression and inducing mitotic arrest. Int J Mol Sci. 2018 Sep 19;19(9). pii: E2832.

Pyo J, Kim W, Choi JS, Jeong JW, Kim JE*. The protein phosphatase PPM1G destabilizes HIF-1a expression. Int J Mol Sci. 2018 Aug 5;19(8). pii: E2297.

Kim W, Pyo J, Noh BJ, Jeong JW, Lee J, Kim JE*. CCAR2 negatively regulates IL-8 production in cervical cancer cells. Oncotarget 2017 Dec 13;9(1):1143-1155.

Choi M(first), Min YH(co-first), Pyo J, Lee CW, Jang CY, Kim JE*. TC Mps1 12, a novel Mps1 inhibitor, suppresses a growth of hepatocellular carcinoma cells via accumulated chromosomal instability. Br J Pharmacol. 2017 Jun;174(12):1810-1825.

Kim W, Cheon MG, Kim JE*. Mitochondrial CCAR2/DBC1 is required for cell survival against rotenone-induced mitochondrial stress. Biochem Biophys Res Commun. 2017 Apr 15;485(4):782-789.

Min YH, Kim W, Kim JE*. The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget 2016 Dec 20; 7(51): 84718-84735.

Bae WY, Choi JS, Kim JE, Park C, Jeong JW. Zingerone suppresses angiogenesis via inhibition of matrix metalloproteinases during tumor development. Oncotarget 2016 Jun 14; 7(30): 47253-47241.

Lee SD, Kim W, Jeong JW, Park JW, Kim JE*. AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia. Cancer Lett 2016 Apr 1;373(1):138-145.

Shin DH, Choi YJ, Jin P, Yoon H, Chun YS, Shin HW, Kim JE, Park JW. Distinct effects of SIRT1 in cancer and stromal cells on tumor promotion. Oncotarget 2016 Mar 14; 7(17):23975-23987.

Bae WY, Choi JS, Kim JE, Jeong JW. Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression. Biochem Pharmacol 2015 Nov 1; 98(1):41-50.

Choi M, Kim W, Cheon MG, Lee CW, Kim JE*. Polo-like kinase 1 inhibitor BI2536 causes mitotic catastrophe following activation of the spindle assembly checkpoint in non-small cell lung cancer cells. Cancer Lett 2015 Feb 28;357(2):591-601.

Cheon MG, Kim W, Choi M, Kim JE*. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett 2015 Jan 28;356(2 Pt B):637-645.

Magni M, Ruscica V, Buscemi G, Kim JE, Nachimuthu BT, Fontanella E, Delia D, Zannini L. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res 2014 Dec 1;42(21):13150-13160.

Kim W, Jeong JW, Kim JE*. CCAR2 deficiency augments genotoxic stress-induced apoptosis in the presence of melatonin in non-small cell lung cancer cells. Tumor Biol 2014 Nov; 35(11):10919-10929.

Kong CS, Kim KH, Choi JS, Kim JE, Park C, Jeong JW. Salicin, an Extract from White Willow Bark, Inhibits Angiogenesis by Blocking the ROS-ERK Pathways. Phytother Res 2014 Aug; 28(8):1246-1251

Kim W, Choi M, Kim JE*. The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle. (Review) Cell Cycle 2014 Mar; 13(5): 726-738.

Kim W, Kim JE*. SIRT7 an emerging sirtuin: Deciphering newer roles. (Review) J Physiol Pharmacol 2013 Oct; 64(5):531-534.

Kim W, Kim JE*. Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage. Cancer Lett 2013 Jun 10; 333(2):180-186.

Zannini L, Buscemi G, Kim JE, Fontanelia E, Delia D. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. J Mol Cell Biol 2012 Oct; 4(5):294-303.

Kim W, Kim R, Park G, Park JW*, Kim JE*. The deficiency of H3K79 histone methyltransferase DOT1L inhibits cell proliferation. J Biol Chem 2012 Feb 17; 287(8):5588-5599.

Park G, Jeong JW, Kim JE*. SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells. FEBS Lett 2011 Jan 3; 585(1):219-224.

Lim JH, Lee YM, Chun YS, Chen J, Kim JE* (co-corresponding), Park JW*. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 2010 Jun 25; 38(6):864-878.

Sung JY, Kim R*(co-first), Kim JE* (co-corresponding), Lee J*. The balance between SIRT1 and DBC1 expression is lost in breast cancer. Cancer Sci 2010 Jul; 101(7):1738-1744.

Park G, Gong Z, Chen J, Kim JE*. Characterization of the DOT1L network: Implications of diverse roles for DOT1L. Protein J 2010 Apr; 29(3):213-223.

Kim JE*, Sung S. Deleted in Breast Cancer 1 (DBC1) is a dynamically regulated protein. Neoplasma 2010;57(4):365-368.

Gong Z, Kim JE, Leung CC, Glover JN, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 2010 Feb 12; 37(3):438-446.

Kim JE*, Lou Z, Chen J. Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells. Cell Cycle 2009 Nov 15; 8(22):3784-3785.

Kim JE* (co-corresponding), Chen J, Lou Z*. p30 DBC is a potential regulator of tumorigenesis (Review). Cell Cycle 2009 Sep 15; 8(18):2932-2935.

Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem 2009 Mar 13; 84(11):7284-7293.

Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhou D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 2008 Apr; 28(8):2825-2839.

Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 2008 Jan 31; 451(7178):583-586.

Botuyan MV*, Lee J*, Ward IM*, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 2006 Dec 29; 127(7):1361-1373. [Recommended in F1000Prime]

Ward I*, Kim JE* (co-first), Minn K, Chini CC, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem 2006 Dec 15; 281(50):38472-38477.

Kim JE, Minter-Dykhouse K, Chen J. Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses (Review). Mol Carcinog 2006 Jun; 45(6):403-408.

Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol 2005 Dec; 25(24):10907-10915. [Recommended in F1000Prime]

Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem 2005 Feb 18; 280(6):5733-5739.

Invited Talks / Poster Presentations / Oral Presentations